Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis
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چکیده
منابع مشابه
exogenous secreted frizzled-related protein-4 modulates steroidogenesis of rat granulosa cells through wnt/bcatenin and pi3k/akt signaling pathways
background: it has been reported that secreted frizzled-related protein-4 known as an antagonist of wnt signaling pathway plays a role in luteinization process of rodent granulosa cells. the purpose of this study was twofold: 1) to determine whether recombinant human secreted frizzled-related protein-4 (rhsfrp-4) could directly induce terminal differentiation of rat granulosa cells (gcs) and 2)...
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The Wnt gene family encodes proteins that serve key roles in differentiation and development. Wnt proteins interact with seven transmembrane receptors of the Frizzled family and activate a signaling pathway leading to the nucleus. A primary biochemical effect of Wnt-1 signaling is the stabilization of cytoplasmic (beta)-catenin which, in association with transcription factors of the Lef/tcf fam...
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Secreted frizzled-related protein 2 (SFRP2) is overexpressed in human angiosarcoma and breast cancer and stimulates angiogenesis via activation of the calcineurin/NFATc3 pathway. There are conflicting reports in the literature as to whether SFRP2 is an antagonist or agonist of β-catenin. The aims of these studies were to assess the effects of SFRP2 antagonism on tumor growth and Wnt-signaling a...
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ژورنال
عنوان ژورنال: Cancer and Metastasis Reviews
سال: 2020
ISSN: 0167-7659,1573-7233
DOI: 10.1007/s10555-020-09941-3